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In Doom (2005), UAC Facility scientist tested their mutations on criminals but they are turning into monsters instead of superhumans. According to Samantha, a scientist working as archaeological staff, a 24th pair chromosome make the human strong & cancerless being.

The extra pair makes her super strong, super fit, super intelligent.

Then why didn't happen like that?

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It's genetic

Grimm determines that their genetics have been altered by the addition of the Martian chromosome; however, the chromosome seems to "choose" whether it causes the person to be superhuman or a monster, apparently able to determine on a genetic level whether a person has the capacity to be evil.

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