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Matt Smith is an English actor known for his role as the Eleventh Doctor in the TV show Doctor Who, and he appears in the film Patient Zero with an American accent.

His voice is very different in this film, and I'm having a hard time believing this is really his voice. It's not the American accent that is different, but the pitch and tone sound like a completely different person.

Did they voice over his lines or is this his real voice?

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All the indications are this this is Smith doing a somewhat interesting American accent. It's not surprising that it's coming off different from his usual English one. It's forced and so it naturally sounds different.

For an example of multiple US accents from Matt Smith see this Youtube clip

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