There are some contradictory things in "Resident Evil: The Final Chapter" that don't match the previous series:
- In "RE: Apocalypse"- we saw that the T-Virus was originated by a Level 6 Umbrella researcher Dr. Charles Ashford in order to heal his daughter Angela from some kind of disease that prevented her from walking.
On the other hand:
- In "RE: Final Chapter" the T-Virus was originated by Dr. James Marcus the owner of Umbrella in order to heal his daughter Alicia, who was suffering from progeria.
So, who made the T-Virus of Resident evil, Dr. James Marcus or Dr. Charles Ashford?