In many films based on Steven King novels, there is an explanation of why stuff exists or is happening. But in 1408 (2007) I've never got an explanation, why the room is cursed exactly, and what makes it evil.
I do know that the room mainly plays with your mind, so you think that all of this is happening, but in reality it's not (except for some things, like Mike's daughter). I still have no idea, what being plays with your mind.