Assuming you can count Stan Lee out, since he makes a cameo in almost every Marvel movie, then without a doubt it's Chris Evans. he
He has played 4 roles derived from comic books,:
Johnny Storm in Fantastic Four (2005) - Based on the Marvel Comics book
Jake Jensen in The Losers (2010) - Based on the Vertigo comic book
Lucas lee in Scott Pilgrim vs The World (2010) - Based on the graphic novel Scott Pilgrim
Steve Rogers in Captain America (2011) - Based on the Marvel Comics book
and (for the sake of completeness) 1 role in a movie which spawned a comic book:
Johnny Storm in Fantastic Four (2005) - Based on the Marvel Comics book
Nick Grant in Push (2009) - Spawned the Wildstorm mini series
Jake Jensen in The Losers (2010) - Based on the Vertigo comic book
Lucas lee in Scott Pilgrim vs The World (2010) - Based on the graphic novel Scott Pilgrim
Steve Rogers in Captain America (2011) - Based on the Marvel Comics book
- Nick Grant in Push (2009) - Spawned the Wildstorm mini series
