Assuming you can count Stan Lee out, since he makes a cameo in almost every Marvel movie, then without a doubt it's Chris Evans.  he has played 4 roles derived from comic books, and 1 role which spawned a comic book:

Johnny Storm in [*Fantastic Four* (2005)](https://en.wikipedia.org/wiki/Fantastic_Four_(2005_film)) - Based on the [Marvel Comics book](https://en.wikipedia.org/wiki/Fantastic_Four)

Nick Grant in [*Push* (2009)](https://en.wikipedia.org/wiki/Push_(2009_film)) - Spawned the [Windstorm mini series](https://en.wikipedia.org/wiki/Push_(2009_film)#Comic) 

Jake Jensen in [*The Losers* (2010)](https://en.wikipedia.org/wiki/The_Losers_(film)) - Based on the [Vertigo comic book](https://en.wikipedia.org/wiki/The_Losers_(Vertigo))

Lucas lee in [*Scott Pilgrim vs The World* (2010)](https://en.wikipedia.org/wiki/Scott_Pilgrim_vs._the_World) - Based on the graphic novel [Scott Pilgrim](https://en.wikipedia.org/wiki/Scott_Pilgrim)

Steve Rogers in [*Captain America* (2011)](https://en.wikipedia.org/wiki/Captain_America:_The_First_Avenger) - Based on the [Marvel Comics book](https://en.wikipedia.org/wiki/Captain_America)