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1994 Movie - Drama/Romance - Starring Tom Hanks, Sally Field, & Robin Wright. The story follows the title character while he is unwittingly at many of history's key events, yet he cannot seem to attract his one true love.

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Out-of-universe for the film, there's this: The 1995 sequel novel (Gump & Co.) says Jenny died of Hepatitis C. So, the "word of God" (from the author) is: Hepatitis C.
answered Aug 17 '15 by Ben Plont