Has there been a case in which a widely famous Hollywood movie was lost and there is no longer a copy of it in existence (physically nor electronically)?

Edit: let's define "famous" as - known enough to make it to imbd's or any other large movie database.

Apologies about the confusion, I must have underestimated the extent of imdb as it indeed lists pretty much everything. What I was looking for is something that is famous enough to be remembered by a wider public and the Star Wars episode listed in one of the comments definitely makes the list!