As per the movie American Made the name of Barry's wife is Lucy... where actually her name was Deborah Seal.
Why did they rename her Lucy in the movie?
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Like the wiki says:
Lucy is loosely based on Barry Seal's third wife Deborah.
So, as any movie that is based on real events, some of the events portrayed in the movies are not always exactly like the real ones.
I think this is the case for the wife, in real life Barry Seal's wife is called Deborah and she is brunette, and in the movie she is called Lucy and she is blonde.
Even Movie Barry is not exactly like Real life Barry, the characters are only inspired by the stories.