Almost certainly not
The "birth" of Killer Frost is explained in the fifth season episode "Icicle cometh" where
Caitlin reunites with her father.
Warning ! Unmarked spoiler ahead
In that episode, we learn that Thomas Snow tried to find a cure to his ALS. Unfortunately, the cure had some side effects and he had to be locked in his lab for years, and the world was lead to believe he was dead.
When a young Caitlin was diagnosed as potentially developing ALS too at a later age, he performed cryogenic experiments on his daughter. Her DNA mutated and she developed the Killer Frost personality as a side effect.
She repressed the memory of Killer Frost for many years but her split personality emerged again during Season 3.
Note: since the timeline of the Seasons 1 and 2, and the timeline after Eobard Thawne reversed Flashpoint are not exactly the same, we cannot be completely sure that Flashpoint is not involved in the process. But we know that there was a Killer Frost on Earth-2 in the timeline before Flashpoint and her family history (dead father and distant mother) is similar on that Earth.