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In one cut scene from Family Guy, Lois says "Chris doesn't take bad news well", then the cut scene occurs in which Lois announces to Chris that his grandfather has died and Chris turns into a reptile and spits black goo on her:

Lois being scared by a reptilian-looking Chris

What is the reference here? Is there a reptile that actually does this, or is it from a movie?

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This is a reference to the dilophosaurus in Jurassic Park.

. Although this dinosaur exists, it did not actually have a folding cowl (this idea was taken from the frill-necked lizard) and it is unknown whether it was venomous.

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