Evolution which I took as director Ivan Reitman's attempt to reboot the GhostBusters franchise. Was a good film (by my standards) and it's been more then ten years now since it's release. Is there any hope or speculation that a sequel will be made?
Considering Evolution was a pretty huge loss for Dreamworks ($40 million return against an $80 million budget (not including marketing)), it is unsurprising that a sequel was not green-lit.
That said, the filmmakers did indeed hope for it to be a new franchise in the same vein as Ghostbusters seeing as they produced a short-lived animated show on Fox Kids based on the film.