What is the history of the genre? What is the chain of works of art, that led to the adult animated sitcoms like Rick and Morty, Beavis and Butt-Head, South Park, etc? Which one was the first?
Let me try to clarify my question. Every work of art is based on some experience of the earlier works. In this case we say that the previous works influenced it. I ask to build the biggest traceable chain of works that leads to Rick and Morty. Of course this question is subjective to some extent, as it always happens when it comes to art. But I would start to build this chain like this:
Rick and Morty ← South Park ← Griffin family ← The Simpsons ← ... ← The Flintstones ← The Honeymooners ← ...
The Simpsons ← St. Trinian's and Molesworth
(Where ← means "is influenced by")
Being a mathematician I would even say that it would not be a chain, but rather a tree. So it may not be convenient to express it as an ordered list.
The question is interesting, because in Russia, for example, we don't have such a tradition of cartoons at all.