I have very little to go on, as I saw this movie when I was very young. Here is what I remember.
I believe it was an American made movie; most likely a low budget straight to video. I'm thinking it was from the 80s, or maybe the early 90s.
I remember two or three guys backpacking for the weekend. I believe the setting was in the American southwest. It was not like a heavy forest, but more of a desert atmosphere. There was maybe a bit of Navajo/Native American motif in there.
I believe they encounter an alien/monster. There are really only two things I can remember about it. For most of the movie, I believe that when they showed the alien, it was from the perspective of the alien. I don't believe you saw the alien until the end. I believe it also had a cloaking/invisibility power; but I'm definitely not thinking of Predator.
I always remembered one of the leads to be Ed Harris, but it's not him, from looking through his filmography.