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In Resident Evil: The Final Chapter, Dr. Isaac points his finger to the bible in the meeting and says these words:

It's been done once before with great success.

character with a finger on a holy bible

Why does he do that?

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It's a reference to the Great Flood and Noah's Ark.

The proposal is to emulate the destruction of humanity by God in the Bible with the exception of a chosen few who were saved in Noah's Ark.

This is actually clear from the dialogue.

I propose that we end the world...

But on our terms. An orchestrated apocalypse.

One that would cleanse the world of its' population but leave its infrastructure and resources intact.

It's been done once before. With great success.

The chosen few will ride out the storm, not in an ark as in the book of Genesis, but in safety.

Underground.

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