In the third episode of the tenth season of The X-Files Mulder and Guy Mann have the following conversation:
MULDER: That's because she used to be... uh, she once... She's transgender.
GUY MANN: (Disbelief) What? You can't transform into a different sex! That's nuts!
MULDER: It's not nuts. It's actually a very common medical procedure. You don't need the surgery, technically...
GUY MANN: (Grabbing at straws) Maybe that's what I could do! It's a cure!
GUY MANN: Well, I've got to stop transforming. I'll do the surgery.
MULDER: Completely different.
GUY MANN: (His mind made up) I don't care how much it costs, I'll do it.
MULDER: They cut off (nodding with his head towards GUY MANN's groin area) your genitals.
GUY MANN: (Thinking about it) Nah, I'll leave it. That's... that's a step too far, isn't it?
I understand that this dialogue is there for the comedic effect and that Guy is grabbing at straws, but even so there should be some logic behind it. When he was trying to force Mulder to puncture his appending with a "lance" it was at least loosely based on the legend, while calling changing his sex "a cure" is lacking any sense to me.