Sheldon Cooper is always shown as struggling when it comes to driving, so is there any particular reason behind that; being one the greatest minds, driving would never have been so difficult. Is there any reason for showing him as bad at driving?
Driving is kind of a social skill. You need to follow some unwritten norms like guessing when the other person is going to turn. And it also needs some level of reliance on your instinct. However, Sheldon takes every calculation to a very scientific and molecular level. He sucks in many situations where you need to interact with other people.
There's a relevant quote by Sheldon in "The Euclid Alternative" -- the fifth episode of the second season -- where he was arguing how he is more evolved to drive:
No, no. Leonard, I’m meant for greater things, like unraveling the mysteries of the universe, not determining when it’s safe to pass a stopped school bus on a country road.
Notice his usage of the word "determining", nobody with driving skills thinks of it in terms of determining. So, indirectly the writers have indicated the reason.
In the prequel show, Young Sheldon s01e03, Sheldon say:
I"ve often been asked
why I never learned to drive a car
this night is your answer.
Why he said that will be a spoiler:
his dad had a heart attack and kids were left in Meemaw's care. But they stole Meemaw's car to see there dad, his older brother George Cooper was driving when he said that due to his rash driving.