As an after the fact answer, having seen the movie, there is multiple instances of Leaning on the Fourth Wall, Breaking the Fourth Wall, and a complete Lack of Fourth Wall, as well as some Lampshade Hanging (A subtle difference from Leaning on the Fourth Wall).
As noted, in the trailers, the "Please don't make my supersuit green or animated" line is an example of Lampshade Hanging, as are the "sewing his mouth shut" moments. These are meta references that the audience knows about, but made some sense in-universe during the movie. The "Cue the Music" is also a Lampshade Hanging.
Once Wade has gone and adapted to being Deadpool, there are several Leaning on the Fourth Wall moments:
Gum on the Car Window/Camera.
Glances towards the camera.
Then there is the direct Fourth Wall breaking:
Deadpool directly speaking or referencing the audience multiple times. The other characters ignore this as typical Wade insanity. These asides are heard by the others but not understood/believed.
And a few moments of No Fourth Wall:
The Breaking the Fourth Wall, while Breaking the Fourth Wall.
The Fast Forward, Rewinds, and movie flashbacks, as referenced by Deadpool.