Skyler's tendencies, particularly in the last two seasons, have a strong escapism theme to them.
With her affair, she ultimately wanted to push back at Walt, but there's a certain element of wanting to be "outside" of her marriage, if only briefly. Her whole impetus for working with Beneke was to earn more money for Walt's treatments, but in many ways, she wanted to get out of the house, back to her old lifestyle, and to dress up.
Her cigarette smoking, weight gain, and change of hairstyle lead up to her "escape" into the pool, and there are many other examples of this as her patience with Walk grows thinner.
All this to say, when he uses the term for (roughly) "Let's Go!", I think her character development would lead us to believe that she really wishes to just get out of the whole mess and leave all of her stressors behind.