It has become clear that events in the Marvel Cinematic Universe can have direct influences in Agents of Shield. I'm interested in the influence in the reverse direction. That is, I consider the following question:
(Q): Are events in AoS consequential to the MCU?
I'm looking for events or clues on past episodes or events that have happened in the MCU or information revealed from the creators, filmmakers, showmakers to answer (Q).
So far, I personally haven't found good support to answer YES to (Q).
p.s. Coulson being made director seems to indicate that the impact is permanent but recent events in S02E04 (I Will Face My Enemy) suggest a possibility that Coulson may eventually be killed (by May). In the MCU, Coulson is dead so if he is killed again in AoS, his resurrection can easily be brushed over.