In the movie, Blade Runner 2049, when K goes back to his apartment complex, there is a sentence written on his door,
I am wondering what 'skinner' means in the Blade Runner universe.
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Per the Blade Runner Wiki
Replicants were sometimes referred to as "skin jobs" or "skinners," as they were indistinguishable from non-engineered humans, except for their empathetic abilities. These terms were considered slurs.
Mentioned in the original Blade Runner. Early replicants weren't especially human-like, but they did have convincing skin.
Bryant: You wouldn't have come if I just asked you to. Sit down pal. C'mon don't be an asshole Deckard. I've got four skin jobs walking the streets.
Deckard (voice-over): Skin jobs, that's what Bryant called replicant. In history books he was the kind of cop that used to call black men niggers.