While I never read/watched it, I know the basic pop culture of 'The Island of Dr. Moreau'. A (mad) scientist, on an island, creates a 'perfect' society of talking animals, that ends up not being so perfect. It's hard not to think about it during Guardians 3, especially during the Counter-earth sequence.
Was the movie (or the original comic story) meant to be a reference to it? Or am I reaching?