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In The Big Bang Theory S04 episode 21, Sheldon Cooper at one point states "I saved a nuns life, why am I being punished?".

Do we ever find out more about this or does the character pop into the series at any point? I am struggling to find anything.

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It's explained in the same episode. Sheldon's talking about an elderly nun whom he saved by giving her mouth-to-mouth resuscitation in a bus.

Penny: Sheldon, have you ever kissed a girl?
Sheldon: Other than my mother, my sister and my Meemaw, no. But in the interest of full disclosure, I was once on a bus and had to give mouth-to-mouth resuscitation to an elderly nun who passed out from heat exhaustion. Every year I get a Christmas card from her, signed with far too many X’s and O’s.

You can refer the script here.

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