In Justice League: the Flashpoint Paradox, as Barry's memories are being replaced we see that night where Bruce's parents would have been murdered, but thanks to the ripples of the altered timeline, it was Bruce who was killed.
As Bruce's mother is holding him, covering her mouth with her bloodied hands, she takes it away and starts laughing hysterically and the blood on her face looks like a smile similar to that of the Joker's while Bruce's Father who's become Batman seems more obsessed in taking down the Joker.
So in the altered timeline did Bruce's mother end up becoming the Joker?