BennyMcBenBen's answerBennyMcBenBen's answer is probably as authoritative as you will get, unless they create a spin off or resurrect the show. But I can answer from other "similar" real life examples.
I saw the movie "The Vow" recently. It was based on a real life event (which was chronicled in a book) where a man's wife lost her entire memory of him. Last thing she remembers is being engaged to another man. Her husband reacted a lot the same way as Chuck - trying to get her to fall in love with him again (except without all the spy stuff).
This movie was also similar that the person she remembered being would never be interested in her current husband. She had forgotten a lot of personal growth and changes she went through that made her the person who fell in love with her husband. Her former fiancee was very successful (much more so than her current husband) and wanted to get back together with her (she dumped him originally).
At the end of the movie we are told that the real life couple it was based on got back together, but she never regained any of her memory.
So in "real life" it has worked out in similar circumstances.