Aside from all the sources that may already corroborate that Prison Break has reached its ending in totality, e.g., IMDB/Wikipedia, it seems exceedingly unlikely that we would see Michael Scofield in action again, as the final episode of Prison break tells us:
Michael hears of the bounty and devises plans for Sara's escape. In the end, knowing that he is dying from a brain tumor, Michael sacrifices himself for his brother, wife and child.
We don't see him die, but we do see Sara and his child at his gravestone, assuredly marking his demise. When we also consider all the other loose ends tied up (other prisoners dying, Lincoln's absolution, deconstruction of 'The Company'), it lends for little further possible plot to continue on.
Update: Prison break going to be revived
One of these unanswered questions that likely immediately jumps to mind is: [SPOILER ALERT] how in the world is Michael still alive? For those that don’t know, “Prison Break” ended with a made for TV movie in which the character sacrifices himself in order to save Lincoln, Sarah (Sara Tancredi) and her unborn child. According to Deadline, the 10-episode event series revival will mostly ignore the events of this finale, but will provide a “logical explanation” as to why the character is alive. However, even if they explain how he survived his death, writers also need to explain how he survived his terminal brain tumor.
