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Converting comment to an answer: It's pretty evident from the statement. He is saying that he is not crazy but rather a very intelligent human being who lacks a sense of moral responsibility or social conscience.


The scene between Sherlock and John, where Sherlock is having an emotional break down in "Hounds of Baskerville", is similar to a scene in an episode of Star Trek called "Naked Time" where Spock has an emotional break down and confesses to feeling shame when he feels friendship towards Jim Kirk, his captain and best friend. In "Baskerville", Sherlock angrily ...


It's because of Moriarty's previous line: Moriarty: Your death is the only thing that's going to call off the killers. I'm certainly not going to do it. The fact that he said "I'm certainly not going to do it" implies he could do it, which means there's something Moriarty could do to stop them, such as give a code word to the assassins, as Sherlock ...


Sherlock likes John because he appreciates him unlike others who call him a freak and ask him to piss off. In the episode A study in Pink, when John and Sherlock are in the cab the following conversation happens: JOHN: That ... was amazing. SHERLOCK: Do you think so? JOHN: Of course it was. It was extraordinary; it was quite extraordinary. ...

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