House (also known as House, M.D.) is an American television medical drama about Dr. Gregory House, a pain medication-dependent, unconventional, misanthropic medical genius who leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

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Is there a significance to Iowa references in House M.D.?

I realize this may be a reach, but I noticed something odd in season 1 of House: In episode 15, there was a mention of Des Moines (Iowa). House: You’re worried about how his coworkers will react ...
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References to Canada in House MD?

Sometimes directors/creators of TV series will throw in Easter eggs of something they like, where they're from etc. For example, in Seinfeld there's quite a few episodes with some sort of Superman ...