The last 2 survivors happens to be on the plane that crashed in the first movie. And it shows all the killing scenes from previous movies after the movie.
Does it mean that this one is the last movie in the series?
No. As long as a franchise remains profitable, there will continue being some way of continuing the series. In FD, there is no physical antagonist chasing you (E.G. Freddy, Jason, Michael Meyers, Alien, Predator... you get the idea), and after the second film, there has been virtually no clear connection between the characters of the first two films and the rest (other than the ending to FD5).
Besides, even when a franchise has more than run its course (think of how many Friday The 13th films there were with the 'original' Jason), there is currently the fashionable idea of 'rebooting' a series. They did it with Halloween, they'll likely do it with FD in another 5-10 years time.
As per Wikipedia page-
That means most probably there may be two more entry in the movie series. As the 5th one is a prequel to the series. Their are rumors for the next one to be a mid-equal (but thats only a rumor).
Final Destination Wikia also says yes for FD6 and FD7.(SOURCE)