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I just saw The Fault in Our Stars and was quite confused with the title in relation to the plot of the movie. Can anyone help me to understand the co-relation between the plot and the title?

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It is from a line from the play Julius Caesar, by Shakespeare:

The fault, dear Brutus, is not in our stars,
But in ourselves, that we are underlings.

Julius Caesar (I, ii, 140-141)

To quote from the eNotes interpretation of the play:

...Cassius continues by reminding Brutus that Caesar is just a man, not a god, and that they are equal men to Caesar. They were all born equally free, and so why would they suddenly have to bow to another man? On another level this phrase has been interpreted to mean that fate is not what drives men to their decisions and actions, but rather the human condition.

In other words, we're to blame for the badness in our lives. We have driven it, through our own actions.

However, the film is based on a book by John Green, who appears to be arguing something different.

Rather than the fault being in ourselves, that the bad stuff is because of us and our choices in life, Green's title suggests the fault is in our stars - that the bad things happen through no fault of our own. That we have little control over our own eventual fate.

The whole novel (and movie) follows this logic and shows the characters leading their lives to the fullest, despite the fault in their stars.

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This distinction is more clear when you recognize that that while Cassius says the fault "is not in our stars", John Green omits the "not". – Tyrsius Feb 15 at 17:15
It's also relevant to note that, elsewhere in Shakespeare's body of work, Romeo and Juliet are referred to as the "star-crossed lovers". Stars represent fate, and you'd want them to align, to smile on you, or at the very least leave you alone. When the stars/fates have faults or are crossed, it's easy to predict an unhappy ending. – raisinghellyer Feb 15 at 19:54

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