In "Mr. Griffin Goes to Washington" (S3E3) Peter takes the whole family to a Baseball game where the Boston Red Sox play against the Yankees.
Chris made a sign to cheer them on which reads John 3:16. Puzzled by what this means, Brian looks up the according part in the bible and reads the verse.
Here is the excerpt from IMDB:
Chris Griffin: [the family is heading to a Boston Red Sox game] Look at what I made!
[Chris holds up a 'John 3:16' sign]
Meg Griffin: What does that mean?
Brian Griffin: [reading John 3:16 from the bible] And the Lord says, 'Go Sox.'
While I find this pretty funny, because it implies that God is a Red Sox fan, I don't really understand the joke.
I looked up the original verse, believing that maybe it was some sort of pun:
For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life.
If it is a pun, I don't see it.
Can somebody explain the joke to me? Why did they choose this specific verse?
The fact that many Family Guy jokes are references to pop culture makes me wonder if this really is just some arbitrary part of the bible that is altered for the laugh itself. Maybe I am overinterpreting it.