This was maybe 20yrs ago. Action sci fi movie. There was one sequel to the first movie. Two organizations had special agents called 'subs'. They were humans combined with animal genetics. The sister was the good agent. I think her character was named Cat or Kat? Actress was dark haired, perhaps Hispanic decent, age approximately 30's. The brother was the bad agent. I think his character was named Cain or Kane. The actor was dark haired, perhaps Italian or Hispanic decent, age approximately 30's. Fight scenes were hand to hand combat, rather than weapons for the most part. I thought the story line was pretty good and it was not a bad movie for it's time. I would like to find it again. Thanks in advance for any guesses.
repfarm, if you're still around, I may have a lead. I stumbled across this and remembered your question: In 1992, George R. R. Martin pitched a sci-fi pilot to ABC called Doorways. It was not picked up but aired as a movie. It was about Cat, a fugitive from a parallel Earth, pursued by the evil 'manhound' Thane after landing in our world. The dark-haired Cat, played by Anne Le Guernec, is described as 'feral':
Dark-haired Thane, played by Robert Knepper, is described by Martin as 'part human, part animal, part cybernetic':
The plot revolved around travelling to parallel worlds through doors a-la Sliders (in fact, Wiki suggests that Sliders may have ripped it off), and according to a couple of reviews I found, it was fairly decent.
Does it ring any bells?
Cyborg 2, (1993), had a character nicknamed "Cash" played by dark-haired Angelina Jolie. Could that be what you're thinking of? It had the two organizations: