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In the movie Repo!: The Genetic Opera Rotti largo says he can't cure himself, so what is he dying from?

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1 Answer 1, which looks at various conventions throughout movies, call it an "Incurable Cough of Death", one of the signs in any movie that a character will not make it to the end. They expand on this though, saying:

Rotti's terminal disease, which is heavily implied to be an untreatable cancer by the doctor's statement, "You don't have a lot of time. It's spreading rapidly."

Ultimately though, his illness is never explicitly stated.

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